"Chemical" by Post Malone is a poignant exploration of addiction, both to substances and toxic relationships. The lyrics depict the artist's struggle with dependency, using oxytocin as a metaphor for the temporary relief he finds in his vices. He acknowledges the destructive cycle he's caught in, breaking his own rules and repeatedly returning to harmful behaviors despite knowing their negative impact. The repeated line "I can't let go, it's chemical" underscores the compulsive nature of addiction and how it feels beyond his control. The song also touches on feelings of regret and desperation for change, yet an inability to escape from this cycle due to what seems like fate or inherent flaws. Overall, it paints a raw picture of the internal conflict experienced by those grappling with addiction.